USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: KAD1_HUMAN USC-OGP 2-DE database:  KAD1_HUMAN KAD1_HUMAN General information about the entry View entry in simple text format Entry name KAD1_HUMAN Primary accession number P00568 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}; Short=AK 1 {ECO:0000255|HAMAP-Rule:MF_03171}; EC=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_03171}; EC=2.7.4.6 {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=ATP-AMP transphosphorylase 1 {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=ATP:AMP phosphotransferase {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=Myokinase {ECO:0000255|HAMAP-Rule:MF_03171};. Gene name Name=AK1 {ECO:0000255|HAMAP-Rule:MF_03171} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1036: pI=8.23; Mw=21887 SPOT OGP-1037: pI=8.35; Mw=21760 Cross-references UniProtKB/Swiss-Prot P00568; KAD1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KAD1_HUMAN Primary accession number P00568 Secondary accession number(s) Q9BVK9 Q9UQC7 Sequence was last modified on  April 16, 2002 (version 3) Annotations were last modified on  March 15, 2017 (version 185) Name and origin of the protein Description RecName: Full=Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}; Short=AK 1 {ECO:0000255|HAMAP-Rule:MF_03171}; EC=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_03171}; EC=2.7.4.6 {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=ATP-AMP transphosphorylase 1 {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=ATP:AMP phosphotransferase {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03171}; AltName: Full=Myokinase {ECO:0000255|HAMAP-Rule:MF_03171}; Gene name Name=AK1 {ECO:0000255|HAMAP-Rule:MF_03171} Encoded on Name=AK1 {ECO:0000255|HAMAP-Rule:MF_03171 Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Hereditary hemolytic anemia; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J04809; AAA51686.1; -; Genomic_DNA EMBL AB021871; BAA78534.1; -; mRNA EMBL BT019580; AAV38387.1; -; mRNA EMBL BC001116; AAH01116.1; -; mRNA CCDS CCDS6881.1; -; . PIR A33508; KIHUA; . RefSeq NP_000467.1; NM_000476.2; . RefSeq NP_001305050.1; NM_001318121.1; . RefSeq XP_016869916.1; XM_017014427.1; . RefSeq XP_016869917.1; XM_017014428.1; . UniGene Hs.175473; -; . PDB 1Z83; X-ray; 1.90 A; A/B/C=1-193 PDB 2C95; X-ray; 1.71 A; A/B=1-193 PDBsum 1Z83; -; . PDBsum 2C95; -; . ProteinModelPortal P00568; -; . SMR P00568; -; . BioGrid 106706; 26; . IntAct P00568; 20; . STRING 9606.ENSP00000362249; -; . ChEMBL CHEMBL4925; -; . DrugBank DB01717; Bis(Adenosine)-5'-Pentaphosphate; . iPTMnet P00568; -; . PhosphoSitePlus P00568; -; . SwissPalm P00568; -; . BioMuta AK1; -; . DMDM 20178288; -; . OGP P00568; -; . REPRODUCTION-2DPAGE IPI00018342; -; . UCD-2DPAGE P00568; -; . EPD P00568; -; . PaxDb P00568; -; . PeptideAtlas P00568; -; . PRIDE P00568; -; . TopDownProteomics P00568; -; . DNASU 203; -; . Ensembl ENST00000373156; ENSP00000362249; ENSG00000106992; . Ensembl ENST00000373176; ENSP00000362271; ENSG00000106992; . GeneID 203; -; . KEGG hsa:203; -; . CTD 203; -; . DisGeNET 203; -; . GeneCards AK1; -; . HGNC HGNC:361; AK1; . HPA CAB009893; -; . HPA HPA006456; -; . MalaCards AK1; -; . MIM 103000; gene; . MIM 612631; phenotype; . neXtProt NX_P00568; -; . OpenTargets ENSG00000106992; -; . Orphanet 86817; Hemolytic anemia due to adenylate kinase deficiency; . PharmGKB PA24655; -; . eggNOG KOG3079; Eukaryota; . eggNOG COG0563; LUCA; . GeneTree ENSGT00390000016215; -; . HOGENOM HOG000238771; -; . HOVERGEN HBG108060; -; . InParanoid P00568; -; . KO K00939; -; . PhylomeDB P00568; -; . TreeFam TF354283; -; . BRENDA 2.7.4.3; 2681; . Reactome R-HSA-499943; Synthesis and interconversion of nucleotide di- and triphosphates; . SABIO-RK P00568; -; . EvolutionaryTrace P00568; -; . GenomeRNAi 203; -; . PRO PR:P00568; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000106992; -; . CleanEx HS_AK1; -; . ExpressionAtlas P00568; baseline and differential; . Genevisible P00568; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0001520; C:outer dense fiber; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0004017; F:adenylate kinase activity; EXP:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004550; F:nucleoside diphosphate kinase activity; IDA:UniProtKB; . GO GO:0046034; P:ATP metabolic process; IEA:InterPro; . GO GO:0007050; P:cell cycle arrest; IEA:Ensembl; . GO GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; . GO GO:0006165; P:nucleoside diphosphate phosphorylation; IDA:UniProtKB; . GO GO:0009142; P:nucleoside triphosphate biosynthetic process; IDA:UniProtKB; . CDD cd01428; ADK; 1; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_00235; Adenylate_kinase_Adk; 1; . HAMAP MF_03171; Adenylate_kinase_AK1; 1; . InterPro IPR000850; Adenylat/UMP-CMP_kin; . InterPro IPR033690; Adenylat_kinase_CS; . InterPro IPR028582; AK1; . InterPro IPR006267; AK1/5; . InterPro IPR027417; P-loop_NTPase; . PANTHER PTHR23359; PTHR23359; 1; . PRINTS PR00094; ADENYLTKNASE; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01360; aden_kin_iso1; 1; . PROSITE PS00113; ADENYLATE_KINASE; 1; .

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